Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines

D Camp; Y Li; A McCluskey; R W Moni; R J Quinn

doi:10.1016/s0960-894x(98)00101-2

Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines

Bioorg Med Chem Lett. 1998 Mar 17;8(6):695-8. doi: 10.1016/s0960-894x(98)00101-2.

Authors

D Camp¹, Y Li, A McCluskey, R W Moni, R J Quinn

Affiliation

¹ Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Australia.

PMID: 9871585
DOI: 10.1016/s0960-894x(98)00101-2

Abstract

Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism
Cells, Cultured
Corpus Striatum / metabolism
Humans
Models, Chemical
Phenylisopropyladenosine / analogs & derivatives*
Phenylisopropyladenosine / metabolism
Purinergic P1 Receptor Agonists*
Pyrimidines / chemical synthesis*
Pyrimidines / metabolism*
Rats
Receptors, Purinergic P1 / metabolism

Substances

Purinergic P1 Receptor Agonists
Pyrimidines
Receptors, Purinergic P1
Phenylisopropyladenosine